Endocrine Abstracts

Section 1: Case history: A 57-year-old female shop assistant presented with a four week history of increasing thirst and lethargy. The patient also reported non-specific pain in her shoulders, ribs and hips. She was otherwise well with no past medical history. Systemic enquiry was unremarkable. On examination nothing abnormal was noted. Specifically there were no rashes, lymphadenopathy or hepatosplenomegaly. Joint examination was normal and there was no muscle tenderness or w...

Although obesity affects men and women, the risks of associated metabolic disturbances (e.g. type 2 diabetes) differ between the sexes. Altered peripheral glucocorticoid metabolism may underpin the metabolic consequences of obesity; however, most research exploring this has focused on male animals. This study used a mouse model to investigate the hypothesis that alterations in glucocorticoid metabolism caused by diet-induced obesity (DIO) will be more profound in males than in...

We have studied 20 patients with autoimmune hypothyroidism on large doses of daily thyroxine that were referred to our departments with concerns regarding possible thyroxine malabsorption or compliance issues. Here we describe 3 patients seen in Oxford. One patient had coeliac disease. The other two patients had no history of malaborption and were coeliac antibody negative. None of the 3 patients were on medication which would interfere with thyroxine absorption. All were fema...